G-L
黄则度 有机化学，副教授，博士生导师
研究兴趣
学术任职
获奖情况
学习工作经历
授课情况
代表性论文或专著
新颖酶催化和生物催化反应的发现与应用
手性药物与手性技术的研究
合成生物学
2003.9-2007.6 浙江大学菠菜平台大全本科，获得学士学位
2007.9-2012.8 加拿大阿尔伯塔大学菠菜平台大全研究生，获得博士学位
2012.11-2016.10 美国伊利诺伊大学香槟分校，博士后
2016.11-2022.11 菠菜平台大全，青年研究员
2022.12起 菠菜平台大全，副教授
本科生必修课程《有机化学》
本科生必修课程《有机化学实验I》
Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370.
Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem. 2023, 25, 3223-3235.
Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustain. Chem. Eng. 2023, doi.org/10.1021/acssuschemeng.3c00985.
Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1 Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289.
Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl -Chloro -Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun. 2022, 58, 9010-9013.
Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal. 2019, 361, 1859-1865.
Wu, X.; Huang, Z.;* Wang, Z.; Li, Z.; Wang, J.; Lin, J.;* Chen, F.* Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. J. Org. Chem. 2020, 85, 5598-5614.
Wu, X.; Li, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Engineered Cyclohexylamine Oxidase with Improved Activity and Stereoselectivity for Asymmetric Synthesis of a Bulky Dextromethorphan Precursor and Its Analogues. ChemCatChem 2022, 14, doi.org/10.1002/cctc.202101970.
Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.
Hu, C.; Ye, B.; Huang, Z.;* Chen, F.* Development Of an Engineered Ketoreductase with Improved Activity, Stereoselectivity and Relieved Substrate Inhibition for Enantioselective Synthesis of a Key (R)--Lipoic Acid Precursor. Mol. Catal. 2022, 522, 112208.