Interrupted Cross Coupling

            Michael Kevin Brown

                 Indiana University

           Department of Chemistry

Stereospecific cross-coupling of chiral alkyl metal intermediates is a recognized challenge in modern organic synthesis. Here an alternative strategy is presented in which a chiral alkyl metal is generated as a catalytic intermediate by boryl-metalation of an alkene followed by cross coupling. This interrupted cross coupling represents an attractive approach in chemical synthesis because two new bonds and two new stereocenters are generated in a single operation.  In addition, due to the synthetic versatility of the carbon-boron bond, a variety of structures can be readily prepared, thus representing a general approach toward carbofunctionalization of alkenes.  The scope, mechanistic details, and application to complex molecule synthesis will be discussed.

Time:10:00am, Tuesday, May 14, 2019

Venue:Room A7032, Chemistry Building

Inviter: Prof. ZHANG Junliang